白细胞介素-22受体亚基α-2 (IL-22 receptor subunit alpha-2) (IL-22R-alpha-2) (IL-22RA2) (细胞因子受体II类成员10) (细胞因子受体家族2成员10) (CRF2-10) (细胞因子受体家族2型可溶性1) (CRF2-S1) (白细胞介素-22结合蛋白) (IL-22BP) (IL22BP) (ZcytoR16)
白细胞介素-22受体亚基α-2 (IL-22 receptor subunit alpha-2) (IL-22R-alpha-2) (IL-22RA2) (细胞因子受体II类成员10) (细胞因子受体家族2成员10) (CRF2-10) (细胞因子受体家族2型可溶性1) (CRF2-S1) (白细胞介素-22结合蛋白) (IL-22BP) (IL22BP) (ZcytoR16)
Q969J5功能描述
异构体 2 是 IL22 的受体。结合 IL22，阻止其与功能性 IL-22R 复合物相互作用，并阻断 IL22 的活性 (体外)。可能作为 IL22 拮抗剂在炎症反应的调节中发挥重要作用。; FUNCTION: 异构体 1 可能在建立和维持成功妊娠中发挥作用。
组织特异性
Expressed in placenta, spleen, breast, skin and lung. Also detected in intestinal tract, testis, brain, heart and thymus. No expression found in prostate, bladder, kidney, ovary, muscle, bone marrow, liver and uterus. Isoform 1 is expressed only in placenta. Isoform 2 is expressed in placenta and breast and at lower level in spleen, skin, thymus and stomach.
亚细胞定位
Secreted
关键词