白细胞介素-22受体亚基α-1 (IL-22受体亚基α-1) (IL-22R-alpha-1) (IL-22RA1) (细胞因子受体II类成员9) (细胞因子受体家族2成员9) (CRF2-9) (ZcytoR11)
白细胞介素-22受体亚基α-1 (IL-22受体亚基α-1) (IL-22R-alpha-1) (IL-22RA1) (细胞因子受体II类成员9) (细胞因子受体家族2成员9) (CRF2-9) (ZcytoR11)
Q8N6P7功能描述
IL20、IL22和IL24受体的组分。由IL22RA1和IL10RB形成的IL22受体的组分，通过JAK/STAT通路实现IL22信号传导。IL22还诱导MAPK1/MAPK3和Akt激酶通路的激活。由IL22RA1和IL20RB形成的IL20和IL24受体之一的组分，也通过STATs激活进行信号传导。介导IL24的抗血管生成活性以及IL24对内皮细胞管形成和分化的抑制作用。 {ECO:0000269|PubMed:11035029, ECO:0000269|PubMed:11564763, ECO:0000269|PubMed:11706020, ECO:0000269|PubMed:12351624, ECO:0000269|PubMed:12941841, ECO:0000269|PubMed:17204547}.
组织特异性
Expressed in colon, liver, lung, pancreas and kidney. No expression in immune cells such as monocytes, T-cells, and NK-cells. Expressed in keratinocytes of normal skin as well as in psoriatic skin lesion. Detected in normal blood brain barrier endothelial cells as well as in multiple sclerosis lesions; Strongly expressed on central nervous system vessels within infiltrated multiple sclerosis lesions. Overexpressed in synovial fluid cells from rheumatoid arthritis and spondyloarthropathy patients.
亚细胞定位
Cell membrane
关键词