白细胞介素-1受体样1 (EC 3.2.2.6) (蛋白ST2)
白细胞介素-1受体样1 (EC 3.2.2.6) (蛋白ST2)
Q01638功能描述
白细胞介素-33 (IL-33) 的受体，在先天免疫和适应性免疫中发挥关键作用，与共受体 IL1RAP 共同维持组织稳态并应对环境应激 (PubMed:35238669)。其激活招募 MYD88、IRAK1、IRAK4 和 TRAF6，随后发生 MAPK3/ERK1 和/或 MAPK1/ERK2、MAPK14 和 MAPK8 的磷酸化。可能参与辅助性T细胞功能 (Probable) (PubMed:16286016)。组织损伤时，诱导 UCP2 依赖性的线粒体重编程，从而减弱活性氧的产生，并维持三羧酸循环的完整性，这是持续产生衣康酸以及随后 GATA3 依赖性的炎症消退型替代激活巨噬细胞分化所必需的 (By similarity)。 {ECO:0000250|UniProtKB:P14719, ECO:0000269|PubMed:16286016, ECO:0000269|PubMed:35238669, ECO:0000305|PubMed:19836339}.; FUNCTION: [Isoform B]: 抑制 IL-33 信号传导。 {ECO:0000250|UniProtKB:P14719}.
组织特异性
Highly expressed in kidney, lung, placenta, stomach, skeletal muscle, colon and small intestine. Isoform A is prevalently expressed in the lung, testis, placenta, stomach and colon. Isoform B is more abundant in the brain, kidney and the liver. Isoform C is not detected in brain, heart, liver, kidney and skeletal muscle. Expressed on T-cells in fibrotic liver; at protein level. Overexpressed in fibrotic and cirrhotic liver.
亚细胞定位
[Isoform C]: Cell membrane.; SUBCELLULAR LOCATION: [Isoform B]: Secreted.; SUBCELLULAR LOCATION: Cell membrane
关键词