白细胞介素-18受体1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218抗原样家族成员A) (CDw218a) (IL1受体相关蛋白) (IL-1Rrp) (IL1R-rp) (白细胞介素-18受体α) (IL-18R-α) (IL-18Rα) (CD抗原CD218a)
白细胞介素-18受体1 (IL-18R-1) (IL-18R1) (EC 3.2.2.6) (CD218抗原样家族成员A) (CDw218a) (IL1受体相关蛋白) (IL-1Rrp) (IL1R-rp) (白细胞介素-18受体α) (IL-18R-α) (IL-18Rα) (CD抗原CD218a)
Q13478功能描述
在IL18受体复合物中，负责结合促炎细胞因子IL18，但不结合IL1A或IL1B (PubMed:14528293, PubMed:25261253, PubMed:25500532, PubMed:37993714, PubMed:8626725)。参与IL18介导的T辅助细胞1 (Th1)合成IFNG (PubMed:10653850)。促进IL18诱导的细胞因子产生，或独立于SLC12A3，或与SLC12A3形成复合物 (By similarity)。 {ECO:0000250|UniProtKB:Q61098, ECO:0000269|PubMed:10653850, ECO:0000269|PubMed:14528293, ECO:0000269|PubMed:25261253, ECO:0000269|PubMed:25500532, ECO:0000269|PubMed:37993714, ECO:0000269|PubMed:8626725}。
组织特异性
Highly expressed in leukocytes, spleen, lung. Also expressed, but at lower levels, in liver, small intestine, colon, prostate, thymus, placenta, and heart. Specifically coexpressed with IL18R1 in Th1 cells (PubMed:10653850, PubMed:10925275, PubMed:11046021).
亚细胞定位
Membrane
关键词