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IL17RE Q8NFR9

白细胞介素-17受体E (IL-17 receptor E) (IL-17RE)

蛋白质信息 (UniProt)

白细胞介素-17受体E (IL-17 receptor E) (IL-17RE)

Q8NFR9

功能描述

IL17C的特异性功能性受体。可能通过NF-kappa-B和MAPK通路进行信号传导。信号传导可能需要TRAF3IP2 /ACT1。可能是针对细菌病原体的先天免疫的关键调节因子。Isoform 2和isoform 4可能是细胞质非活性形式或显性活性形式。Isoform 3和isoform 5可能作为可溶性诱饵受体。 {ECO:0000269|PubMed:21993848, ECO:0000269|PubMed:21993849}。

组织特异性

Predominantly expressed in mucosal tissues with high levels in keratinocytes and colon epithelial cells. Very low expression in dermal fibroblasts. Expressed in various tumor cell lines.

亚细胞定位

[Isoform 1]: Cell membrane

关键词

Alternative splicing Cell membrane Cytoplasm Glycoprotein Inflammatory response Membrane Proteomics identification Receptor Reference proteome Secreted