锌指蛋白Helios (Ikaros家族锌指蛋白2)
锌指蛋白Helios (Ikaros家族锌指蛋白2)
Q9UKS7功能描述
转录因子，可稳定调节性T细胞(Tregs)的非炎性表型 (By similarity)。可能通过STAT5介导的信号通路发挥作用 (By similarity)。结合IL2启动子并抑制其转录，可能是通过表观遗传沉默，诱导IL2启动子中核心组蛋白的去乙酰化 (PubMed:37316189)。在Tregs中，是FOXP3募集至IL2启动子所必需的 (By similarity)。是外毛细胞成熟及随后的听觉功能所必需的 (By similarity)。 {ECO:0000250|UniProtKB:P81183, ECO:0000269|PubMed:37316189}。
组织特异性
Expressed in various types of T cells, including developping thymocytes, activated T cells and regulatory T cells (PubMed:34826260). Expressed in mucosal-associated invariant T (MAIT) cells both during their thymic development and their activation in the periphery (PubMed:34826260).
亚细胞定位
Nucleus
关键词