IGHMBP2 P38935

DNA结合蛋白SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP依赖性解旋酶IGHMBP2) (神经胶质因子1) (GF-1) (免疫球蛋白μ结合蛋白2)

蛋白质信息 (UniProt)

DNA结合蛋白SMUBP-2 (EC 3.6.4.12) (EC 3.6.4.13) (ATP依赖性解旋酶IGHMBP2) (神经胶质因子1) (GF-1) (免疫球蛋白μ结合蛋白2)

P38935

功能描述

5'至3'解旋酶，在ATP依赖性反应中解旋RNA和DNA双链 (PubMed:19158098, PubMed:22999958, PubMed:30218034)。特异性作用于5'-磷酸化的单链富鸟嘌呤序列 (PubMed:22999958, PubMed:8349627)。可能在RNA代谢、核糖体生物合成或翻译起始中发挥作用 (PubMed:19158098, PubMed:19299493)。可能在转录调控中发挥作用 (By similarity)。与tRNA-Tyr相互作用 (PubMed:19299493)。 {ECO:0000250|UniProtKB:Q9EQN5, ECO:0000269|PubMed:19158098, ECO:0000269|PubMed:19299493, ECO:0000269|PubMed:22999958, ECO:0000269|PubMed:30218034, ECO:0000269|PubMed:8349627}。

组织特异性

Expressed in all tissues examined. Expressed in the developing and adult human brain, with highest expression in the cerebellum. Moderately expressed in fibroblasts.

亚细胞定位

Nucleus

关键词

3D-structure Acetylation Activator ATP-binding Cell projection Charcot-Marie-Tooth disease Cytoplasm Direct protein sequencing Disease variant DNA-binding

外部链接

UniProt: P38935

NCBI Gene

GeneCards