IGF2BP3 O00425

胰岛素样生长因子2 mRNA结合蛋白3 (IGF2 mRNA结合蛋白3) (IMP-3) (IGF-II mRNA结合蛋白3) (癌症中过表达的KH结构域蛋白) (hKOC) (VICKZ家族成员3)

功能描述

RNA结合因子，可将靶转录本募集至细胞质蛋白-RNA复合物 (mRNPs)。这种将转录本“囚禁”入mRNPs的机制允许mRNA的转运和暂时储存。它还调节靶转录本遭遇翻译装置的速度和位置，并保护它们免受核酸内切酶攻击或microRNA介导的降解。优先结合含有N6-甲基腺苷 (m6A) 的mRNA并增加其稳定性 (PubMed:29476152)。结合CD44 mRNA的3'-UTR并使其稳定，从而促进癌细胞的细胞粘附和侵袭伪足形成。结合beta-actin/ACTB和MYC转录本。通过结合编码区不稳定决定子 (CRD) 增加MYC mRNA的稳定性，且CRD的m6A修饰会增强这种结合 (PubMed:29476152)。结合胰岛素样生长因子2 (IGF2) mRNA的5'-UTR。 {ECO:0000269|PubMed:16541107, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152}。

组织特异性

Expressed in fetal liver, fetal lung, fetal kidney, fetal thymus, fetal placenta, fetal follicles of ovary and gonocytes of testis, growing oocytes, spermatogonia and semen (at protein level). Expressed in cervix adenocarcinoma, in testicular, pancreatic and renal-cell carcinomas (at protein level). Expressed ubiquitously during fetal development at 8 and 14 weeks of gestation. Expressed in ovary, testis, brain, placenta, pancreatic cancer tissues and pancreatic cancer cell lines.

亚细胞定位

Nucleus. Cytoplasm. Cytoplasm, P-body