胰岛素样生长因子2 mRNA结合蛋白2 (IGF2 mRNA-binding protein 2) (IMP-2) (肝细胞癌自身抗原p62) (IGF-II mRNA结合蛋白2) (VICKZ家族成员2)
胰岛素样生长因子2 mRNA结合蛋白2 (IGF2 mRNA-binding protein 2) (IMP-2) (肝细胞癌自身抗原p62) (IGF-II mRNA结合蛋白2) (VICKZ家族成员2)
Q9Y6M1功能描述
RNA结合因子，将靶转录本募集到细胞质蛋白-RNA复合物 (mRNPs) 中。这种转录本“笼式包裹”进入mRNPs的过程允许mRNA转运和短暂储存。它还调节靶转录本遭遇翻译装置的速率和位置，并保护它们免受核酸内切酶攻击或microRNA介导的降解 (By similarity)。优先结合含有N6-甲基腺苷 (m6A) 的mRNA并增加其稳定性 (PubMed:29476152)。结合胰岛素样生长因子2 (IGF2) mRNA的5'-UTR (PubMed:9891060)。结合具有亚型特异性。结合beta-actin/ACTB和MYC转录本。通过结合编码区不稳定决定簇 (CRD) 增加MYC mRNA的稳定性，且CRD的m6A修饰增强了结合 (PubMed:29476152)。 {ECO:0000250, ECO:0000269|PubMed:23640942, ECO:0000269|PubMed:29476152, ECO:0000269|PubMed:9891060}。
组织特异性
Expressed in oocytes, granulosa cells of small and growing follicles, Leydig cells, spermatogonia and semen (at protein level). Expressed in testicular cancer (at protein level). Expressed weakly in heart, placenta, skeletal muscle, bone marrow, colon, kidney, salivary glands, testis and pancreas. Detected in fetal liver, fetal ovary, gonocytes and interstitial cells of the testis.
亚细胞定位
Nucleus. Cytoplasm. Cytoplasm, P-body
关键词