鞭毛内运输蛋白81同源物 (肉碱缺乏症相关心室表达蛋白1) (CDV-1)
鞭毛内运输蛋白81同源物 (肉碱缺乏症相关心室表达蛋白1) (CDV-1)
Q8WYA0功能描述
鞭毛内运输(intraflagellar transport, IFT)复合体B的组分：与IFT74一起，形成一个tubulin结合模块，特异性介导tubulin在纤毛内的运输。通过其CH(calponin-homology)样区域结合tubulin (PubMed:23990561)。为纤毛发生所必需 (PubMed:23990561, PubMed:27666822)。为SHH信号通路的正确调控所必需 (PubMed:27666822)。通过调节精子鞭毛的组装和伸长，在精子发生过程中发挥重要作用 (By similarity)。 {ECO:0000250|UniProtKB:O35594, ECO:0000269|PubMed:23990561, ECO:0000269|PubMed:27666822}。
组织特异性
Highly expressed in testis, moderately in ovary, heart, liver, skeletal muscle, kidney and pancreas, low in prostate, brain, placenta and lung and not detected in spleen, thymus, small intestine and colon. Isoform CDV-1R is abundantly expressed in testis.
亚细胞定位
Cell projection, cilium
关键词