IFNAR1 P17181

α/β干扰素受体1 (IFN-R-1) (IFN-α/β受体1) (细胞因子受体II类成员1) (细胞因子受体家族2成员1) (CRF2-1) (I型干扰素受体1)

功能描述

与IFNAR2共同形成I型干扰素（包括干扰素alpha、beta、epsilon、omega和kappa）的异二聚体受体 (PubMed:10049744, PubMed:14532120, PubMed:15337770, PubMed:2153461, PubMed:21854986, PubMed:24075985, PubMed:31270247, PubMed:33252644, PubMed:35442418, PubMed:7813427)。I型干扰素结合激活JAK-STAT信号级联反应，导致干扰素调节基因的转录激活或抑制，这些基因编码干扰素反应的效应因子 (PubMed:10049744, PubMed:21854986, PubMed:7665574)。机制上，I型干扰素结合使IFNAR1和IFNAR2亚基彼此紧密靠近，驱动其关联的Janus激酶 (JAKs)（结合于IFNAR1的TYK2和结合于IFNAR2的JAK1）相互交叉磷酸化 (PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427)。激活的激酶磷酸化IFNAR1和IFNAR2胞内结构域上的特定酪氨酸残基，形成STAT转录因子的停泊位点 (PubMed:21854986, PubMed:32972995, PubMed:7526154, PubMed:7665574, PubMed:7813427)。随后STAT蛋白被JAKs磷酸化，促进其易位至细胞核以调节干扰素调节基因的表达 (PubMed:19561067, PubMed:21854986, PubMed:32972995, PubMed:7665574, PubMed:7813427, PubMed:9121453)。也可不依赖IFNAR2发挥作用：单独形成有活性的IFNB1受体并激活不涉及JAK-STAT通路激活的信号级联反应 (By similarity)。 {ECO:0000250|UniProtKB:P33896, ECO:0000269|PubMed:10049744, ECO:0000269|PubMed:14532120, ECO:0000269|PubMed:15337770, ECO:0000269|PubMed:19561067, ECO:0000269|PubMed:2153461, ECO:0000269|PubMed:21854986, ECO:0000269|PubMed:24075985, ECO:0000269|PubMed:31270247, ECO:0000269|PubMed:32972995, ECO:0000269|PubMed:33252644, ECO:0000269|PubMed:35442418, ECO:0000269|PubMed:7526154, ECO:0000269|PubMed:7665574, ECO:0000269|PubMed:7813427, ECO:0000269|PubMed:9121453}。

组织特异性

IFN receptors are present in all tissues and even on the surface of most IFN-resistant cells. Isoform 1, isoform 2 and isoform 3 are expressed in the IFN-alpha sensitive myeloma cell line U266B1. Isoform 2 and isoform 3 are expressed in the IFN-alpha resistant myeloma cell line U266R. Isoform 1 is not expressed in IFN-alpha resistant myeloma cell line U266R.

亚细胞定位

[Isoform 1]: Cell membrane