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ICMT O60725

蛋白质-S-异戊烯半胱氨酸O-甲基转移酶 (EC 2.1.1.100) (异戊烯半胱氨酸羧甲基转移酶) (异戊烯化蛋白质羧基甲基转移酶) (PPMT) (异戊烯半胱氨酸羧基甲基转移酶) (pcCMT)

蛋白质信息 (UniProt)

蛋白质-S-异戊烯半胱氨酸O-甲基转移酶 (EC 2.1.1.100) (异戊烯半胱氨酸羧甲基转移酶) (异戊烯化蛋白质羧基甲基转移酶) (PPMT) (异戊烯半胱氨酸羧基甲基转移酶) (pcCMT)

O60725

功能描述

催化异戊烯化C末端半胱氨酸残基的翻译后甲基化。 {ECO:0000269|PubMed:9614111}。

组织特异性

Ubiquitously expressed. Expressed at higher levels in the cerebellum and putamen than in other brain regions. Abundant expression seen in the Purkinje cells and pontine neurons.

亚细胞定位

Endoplasmic reticulum membrane

关键词

Endoplasmic reticulum Membrane Methyltransferase Proteomics identification Reference proteome S-adenosyl-L-methionine Transferase Transmembrane Transmembrane helix