缺氧上调蛋白1 (150 kDa氧调节蛋白) (ORP-150) (170 kDa葡萄糖调节蛋白) (GRP-170) (热休克蛋白家族H成员4)
缺氧上调蛋白1 (150 kDa氧调节蛋白) (ORP-150) (170 kDa葡萄糖调节蛋白) (GRP-170) (热休克蛋白家族H成员4)
Q9Y4L1功能描述
在缺氧引发的细胞保护机制中起关键作用。促进HSPA5/BiP介导的ATP核苷酸交换，从而在内质网应激存在时激活未折叠蛋白反应(UPR)通路 (By similarity)。可能作为分子伴侣发挥作用并参与蛋白质折叠。 {ECO:0000250|UniProtKB:Q9JKR6, ECO:0000269|PubMed:10037731}。
组织特异性
Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.
亚细胞定位
Endoplasmic reticulum lumen.
关键词