3-酮类固醇还原酶/17-β-羟基类固醇脱氢酶7 (17-β-羟基类固醇脱氢酶7) (17-β-HSD 7) (3-酮类固醇还原酶) (EC 1.1.1.270) (双氢睾酮氧化还原酶) (EC 1.1.1.210) (雌二醇17-β-脱氢酶7) (EC 1.1.1.62) (短链脱氢酶/还原酶家族37C成员1)
3-酮类固醇还原酶/17-β-羟基类固醇脱氢酶7 (17-β-羟基类固醇脱氢酶7) (17-β-HSD 7) (3-酮类固醇还原酶) (EC 1.1.1.270) (双氢睾酮氧化还原酶) (EC 1.1.1.210) (雌二醇17-β-脱氢酶7) (EC 1.1.1.62) (短链脱氢酶/还原酶家族37C成员1)
P56937功能描述
参与类固醇激素代谢和胆固醇生物合成的双功能酶 (PubMed:11165030, PubMed:12574203, PubMed:12732193, PubMed:12829805, PubMed:19772289, PubMed:20659585)。催化雌激素和雄激素的NADP(H)依赖性还原，并调节这些类固醇的生物活性。将雌酮 (E1) 转化为效力更强的雌激素17β-雌二醇 (E2) (PubMed:12574203, PubMed:12732193, PubMed:19772289)。将双氢睾酮 (DHT) 转化为其无活性形式5α-雄烷-3β,17β-二醇 (PubMed:12574203, PubMed:12732193, PubMed:19772289)。中度将孕酮转化为3β-羟基孕-4-烯-20-酮，导致其失活 (PubMed:12574203, PubMed:12732193)。此外，作为3-酮类固醇还原酶参与角鲨烯后的胆固醇生物合成 (PubMed:11165030, PubMed:12829805, PubMed:20659585)。 {ECO:0000269|PubMed:11165030, ECO:0000269|PubMed:12574203, ECO:0000269|PubMed:12732193, ECO:0000269|PubMed:12829805, ECO:0000269|PubMed:19772289, ECO:0000269|PubMed:20659585}.; FUNCTION: [Isoform 3]: 对E1和DHT没有酶活性。 {ECO:0000269|PubMed:12732193}.
组织特异性
Highly expressed in adrenal gland, liver, lung and thymus. Expressed in breast, ovaries, pituitary gland, pregnant uterus, prostate, kidney, lymph node, small intestine, spinal cord and trachea. Weakly expressed in all other tissues tested.
亚细胞定位
Endoplasmic reticulum membrane
关键词