雌二醇17-β-脱氢酶11 (EC 1.1.1.62) (17-β-羟基类固醇脱氢酶11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-β-羟基类固醇脱氢酶XI) (17-beta-HSD XI) (17betaHSDXI) (皮肤T细胞淋巴瘤相关抗原HD-CL-03) (CTCL相关抗原HD-CL-03) (脱氢酶/还原酶SDR家族成员8) (视网膜短链脱氢酶/还原酶2) (retSDR2) (短链脱氢酶/还原酶家族16C成员2)
雌二醇17-β-脱氢酶11 (EC 1.1.1.62) (17-β-羟基类固醇脱氢酶11) (17-beta-HSD 11) (17bHSD11) (17betaHSD11) (17-β-羟基类固醇脱氢酶XI) (17-beta-HSD XI) (17betaHSDXI) (皮肤T细胞淋巴瘤相关抗原HD-CL-03) (CTCL相关抗原HD-CL-03) (脱氢酶/还原酶SDR家族成员8) (视网膜短链脱氢酶/还原酶2) (retSDR2) (短链脱氢酶/还原酶家族16C成员2)
Q8NBQ5功能描述
在体外能将雄烷-3-α,17-β-二醇 (3-alpha-diol) 转化为雄酮，表明它可能参与类固醇生成过程中的雄激素代谢。可能通过代谢刺激类固醇合成的化合物和/或产生抑制类固醇合成的代谢产物来发挥作用。对DHEA (脱氢表雄酮) 或 A-dione (4-雄烯-3,17-二酮) 无活性，对睾酮转化为A-dione仅有微弱活性。皮肤T细胞淋巴瘤中的肿瘤相关抗原。
组织特异性
Present at high level in steroidogenic cells such as syncytiotrophoblasts, sebaceous gland, Leydig cells, and granulosa cells of the dominant follicle and corpus luteum. In lung, it is detected in the ciliated epithelium and in acini of adult trachea, in bronchioles, but not in alveoli. In the eye, it is detected in the nonpigmented epithelium of the ciliary body and, at lower level, in the inner nuclear layer of the retina (at protein level). Widely expressed. Highly expressed in retina, pancreas, kidney, liver, lung, adrenal, small intestine, ovary and heart.
亚细胞定位
Endoplasmic reticulum
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