组胺H3受体 (H3R) (HH3R) (G蛋白偶联受体97)
组胺H3受体 (H3R) (HH3R) (G蛋白偶联受体97)
Q9Y5N1功能描述
组胺受体的H3亚类可介导中枢神经系统和周围神经系统中的组胺信号。通过抑制腺苷酸环化酶进行信号传导，并显示较高的组成型活性（在无激动剂情况下的自发活性）。亚型3的激动剂刺激既未改变腺苷酸环化酶活性，也未诱导细胞内钙动员。
组织特异性
Expressed predominantly in the CNS, with the greatest expression in the thalamus and caudate nucleus. The various isoforms are mainly coexpressed in brain, but their relative expression level varies in a region-specific manner. Isoform 3 and isoform 7 are highly expressed in the thalamus, caudate nucleus and cerebellum while isoform 5 and isoform 6 show a poor expression. Isoform 5 and isoform 6 show a high expression in the amygdala, substantia nigra, cerebral cortex and hypothalamus. Isoform 7 is not found in hypothalamus or substantia nigra.
亚细胞定位
Cell membrane; Multi-pass membrane protein.
关键词