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HR O43593

赖氨酸特异性去甲基化酶无毛蛋白 (EC 1.14.11.65) ([组蛋白H3]-二甲基-L-赖氨酸(9)去甲基化酶无毛蛋白)

蛋白质信息 (UniProt)

赖氨酸特异性去甲基化酶无毛蛋白 (EC 1.14.11.65) ([组蛋白H3]-二甲基-L-赖氨酸(9)去甲基化酶无毛蛋白)

O43593

功能描述

组蛋白去甲基化酶,特异性去除组蛋白H3 'Lys-9' 的一甲基和二甲基修饰。可能作为转录调节因子控制毛发生物学(通过靶向胶原蛋白)、神经活动和细胞周期。{ECO:0000269|PubMed:24334705}。

组织特异性

Strongest expression of isoforms 1 and 2 is seen in the small intestine, weaker expression in brain and colon, and trace expression is found in liver, pancreas, spleen, thymus, stomach, salivary gland, appendix and trachea. Isoform 1 is always the most abundant. Isoform 1 is exclusively expressed at low levels in kidney and testis. Isoform 2 is exclusively expressed at high levels in the skin.

亚细胞定位

Nucleus.

关键词

Alternative splicing Disease variant DNA-binding Hypotrichosis Iron Metal-binding Nucleus Oxidoreductase Proteomics identification Reference proteome