HJURP Q8NCD3

Holliday junction识别蛋白 (14-3-3相关AKT底物) (胎肝表达基因1蛋白) (肺癌上调9)

功能描述

着丝粒蛋白，在着丝粒组蛋白H3样变体CENPA的掺入和维持中发挥核心作用。作为CENPA的特异性分子伴侣，是新合成的CENPA分子掺入复制后的着丝粒核小体所必需的。阻止CENPA-H4四聚体化，并防止CENPA-H4四聚体过早结合DNA。直接结合Holliday连接。 {ECO:0000269|PubMed:19410544, ECO:0000269|PubMed:19410545}。

组织特异性

According to PubMed:17256767, highly expressed in the thymus with lower levels in the placenta, small intestine, liver, skeletal muscle, and colon. According to PubMed:17823411, highly expressed in testis, and at a relatively lower level in thymus and bone marrow. Significantly overexpressed in many lung cancer samples, compared with normal lung.

亚细胞定位

Nucleus, nucleolus. Chromosome, centromere. Note=Localizes in centromeres during late telophase and early G1, when CENPA nucleosomes are assembled. Localizes to nucleolus during S phase, nucleolus site being often related to storage.