HIRA P54198

HIRA蛋白 (TUP1样分裂增强蛋白1)

功能描述

与ASF1A协作促进不依赖复制的染色质组装。细胞周期中组蛋白基因转录的周期性抑制所必需。衰老相关异染色质灶（SAHF）的形成及有效的衰老相关细胞周期退出所必需。 {ECO:0000269|PubMed:12370293, ECO:0000269|PubMed:14718166, ECO:0000269|PubMed:15621527}.

组织特异性

Expressed at high levels in kidney, pancreas and skeletal muscle and at lower levels in brain, heart, liver, lung, and placenta.

亚细胞定位

Nucleus. Nucleus, PML body. Note=Primarily, though not exclusively, localized to the nucleus. Localizes to PML bodies immediately prior to onset of senescence.