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HIP1R O75146

亨廷顿蛋白相互作用蛋白1相关蛋白 (HIP1相关蛋白) (亨廷顿蛋白相互作用蛋白12) (HIP-12)

蛋白质信息 (UniProt)

亨廷顿蛋白相互作用蛋白1相关蛋白 (HIP1相关蛋白) (亨廷顿蛋白相互作用蛋白12) (HIP-12)

O75146

功能描述

网格蛋白包被凹陷和小泡的组分,可能将内吞机制连接到肌动蛋白细胞骨架。结合3-磷酸肌醇(通过ENTH结构域)。可能通过ENTH结构域发挥作用,在配体诱导的内吞作用后稳定受体酪氨酸激酶以促进细胞存活。 {ECO:0000269|PubMed:11889126, ECO:0000269|PubMed:14732715}。

组织特异性

Brain, heart, kidney, pancreas, and liver, but not in lung or placenta.

亚细胞定位

Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.

关键词

3D-structure Acetylation Actin-binding Alternative splicing Coiled coil Cytoplasm Cytoplasmic vesicle Direct protein sequencing Endocytosis Membrane