缺氧诱导脂滴相关蛋白 (缺氧诱导基因2蛋白)
缺氧诱导脂滴相关蛋白 (缺氧诱导基因2蛋白)
Q9Y5L2功能描述
增加细胞内脂质积累。刺激包括IL6、MIF和VEGFA在内的细胞因子表达。增强细胞生长和增殖。{ECO:0000269|PubMed:15930302, ECO:0000269|PubMed:20624928}。
组织特异性
Highly expressed in renal cell carcinoma cells but barely detectable in adjacent normal kidney tissue. Detected in some cervical and endometrial cancers. Expression also detected in fetal kidney with little or no expression observed in normal adult heart, liver, lung, pancreas, prostate or spinal cord (at protein level).
亚细胞定位
Lipid droplet. Secreted. Membrane
关键词