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HHLA2 Q9UM44

HERV-H LTR关联蛋白2 (人内源性逆转录病毒-H长末端重复序列关联蛋白2)

蛋白质信息 (UniProt)

HERV-H LTR关联蛋白2 (人内源性逆转录病毒-H长末端重复序列关联蛋白2)

Q9UM44

功能描述

通过与TMIGD2相互作用,在TCR介导的激活背景下共刺激T细胞。通过AKT依赖的信号级联反应增强T细胞增殖和细胞因子产生。 {ECO:0000269|PubMed:23784006}。

组织特异性

Expressed at high levels in colon, kidney, testis, lung and pancreas, and at lower levels in small intestine, liver and skeletal muscle. In immune cells, highly expressed in B-cells, dendritic cells and macrophages. Not detected in T-cells.

亚细胞定位

Membrane

关键词

Alternative splicing Disulfide bond Glycoprotein Immunoglobulin domain Membrane Proteomics identification Reference proteome Repeat Signal Transmembrane