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HEY2 Q9UBP5

含YRPW基序的Hairy/enhancer-of-split相关蛋白2 (心血管螺旋-环-螺旋因子1) (hCHF1) (B类碱性螺旋-环-螺旋蛋白32) (bHLHb32) (HES相关阻遏蛋白2) (Hairy and enhancer of split相关蛋白2) (HESR-2) (Hairy相关转录因子2) (HRT-2) (hHRT2) (Gridlock同源蛋白)

蛋白质信息 (UniProt)

含YRPW基序的Hairy/enhancer-of-split相关蛋白2 (心血管螺旋-环-螺旋因子1) (hCHF1) (B类碱性螺旋-环-螺旋蛋白32) (bHLHb32) (HES相关阻遏蛋白2) (Hairy and enhancer of split相关蛋白2) (HESR-2) (Hairy相关转录因子2) (HRT-2) (hHRT2) (Gridlock同源蛋白)

Q9UBP5

功能描述

Notch信号的下游效应因子，可能为心血管发育所必需。转录抑制因子，优先结合经典E box序列5'-CACGTG-3'。抑制心脏转录激活因子GATA4和GATA6的转录。 {ECO:0000269|PubMed:10692439, ECO:0000269|PubMed:11095750, ECO:0000269|PubMed:15485867, ECO:0000269|PubMed:16293227}。

亚细胞定位

Nucleus

关键词

Developmental protein DNA-binding Notch signaling pathway Nucleus Proteomics identification Reference proteome Repressor Transcription Transcription regulation

外部链接

UniProt: Q9UBP5
NCBI Gene