下丘脑分泌素神经肽前体 (Hypocretin) (Hcrt) (食欲素前体) (Prepro-orexin) (前下丘脑分泌素) [酶切产生：食欲素-A (Hypocretin-1) (Hcrt1); 食欲素-B (Hypocretin-2) (Hcrt2)]
下丘脑分泌素神经肽前体 (Hypocretin) (Hcrt) (食欲素前体) (Prepro-orexin) (前下丘脑分泌素) [酶切产生：食欲素-A (Hypocretin-1) (Hcrt1); 食欲素-B (Hypocretin-2) (Hcrt2)]
O43612功能描述
在摄食和睡眠-觉醒调节中发挥重要作用的神经肽，可能通过协调这些互补稳态功能的复杂行为和生理反应来实现。也有观点认为其在能量代谢、自主神经功能、激素平衡和体液调节的稳态调节中具有更广泛的作用。 {ECO:0000250|UniProtKB:O55232}.; FUNCTION: [Orexin-A]: 以高亲和力结合食欲素受体 HCRTR1/OX1R 和 HCRTR2/OX2R (By similarity)。刺激摄食 (By similarity)。以依赖卵巢类固醇的方式调节垂体黄体生成素分泌 (By similarity)。 {ECO:0000250|UniProtKB:O55232}.; FUNCTION: [Orexin-B]: 仅结合食欲素受体 HCRTR2/OX2R (By similarity)。刺激摄食 (By similarity)。以依赖卵巢类固醇的方式调节垂体黄体生成素分泌 (By similarity)。 {ECO:0000250|UniProtKB:O55232}.
组织特异性
Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas.
亚细胞定位
Rough endoplasmic reticulum
关键词