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HCN4 Q9Y3Q4

钾/钠超极化激活环核苷酸门控通道4

蛋白质信息 (UniProt)

钾/钠超极化激活环核苷酸门控通道4

Q9Y3Q4

功能描述

超极化激活的离子通道,对Na(+)和K(+)离子通透,具有非常缓慢的激活和失活特性 (PubMed:10228147, PubMed:10430953, PubMed:20829353)。对K(+)离子表现出高于Na(+)离子的选择性 (PubMed:10228147)。参与心脏中调节心跳节律的天然起搏电流 (If) (Probable) (PubMed:10228147, PubMed:16407510, PubMed:19165230)。参与神经元中的天然起搏电流 (Ih) (Probable)。可能介导对酸味刺激的反应 (By similarity)。 {ECO:0000250|UniProtKB:Q9JKA7, ECO:0000269|PubMed:10228147, ECO:0000269|PubMed:10430953, ECO:0000269|PubMed:16407510, ECO:0000269|PubMed:19165230, ECO:0000269|PubMed:20829353, ECO:0000305|PubMed:10430953}。

组织特异性

Highly expressed in thalamus, testis and in heart, both in ventricle and atrium. Detected at much lower levels in amygdala, substantia nigra, cerebellum and hippocampus.

亚细胞定位

Cell membrane

关键词

3D-structure Brugada syndrome cAMP cAMP-binding Cell membrane Disease variant Epilepsy Glycoprotein Ion channel Ion transport