钾/钠超极化激活环核苷酸门控通道1 (脑环核苷酸门控通道1) (BCNG-1)
钾/钠超极化激活环核苷酸门控通道1 (脑环核苷酸门控通道1) (BCNG-1)
O60741功能描述
超极化激活的离子通道，对钠离子和钾离子具有通透性 (PubMed:15351778, PubMed:28086084)。对K(+)离子的选择性低于Na(+)离子 (PubMed:28086084)。参与心脏天然起搏电流(If)以及控制神经元兴奋性的I(h)电流的产生 (PubMed:29936235, PubMed:30351409)。参与小脑运动学习机制 (By similarity)。可能介导对酸味刺激的反应 (By similarity)。 {ECO:0000250|UniProtKB:O88704, ECO:0000269|PubMed:15351778, ECO:0000269|PubMed:28086084, ECO:0000269|PubMed:29936235, ECO:0000269|PubMed:30351409}。
组织特异性
Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas.
亚细胞定位
Cell membrane
关键词