GPR75 O95800

可能的G蛋白偶联受体75

功能描述

功能：由趋化因子CCL5/RANTES激活的G蛋白偶联受体。可能与异源三聚体Gq蛋白偶联，激活后刺激三磷酸肌醇产生和钙动员。与CCL5/RANTES一起，可能通过激活涉及PI3、Akt和MAP激酶的下游信号通路，在神经元存活中发挥作用。CCL5/RANTES也可能通过激活该受体来调节胰岛细胞的胰岛素分泌。 {ECO:0000250|UniProtKB:Q6X632, ECO:0000303|PubMed:23979485}。

组织特异性

Expressed at high levels in brain and spinal cord and at detectable levels in retinal pigment epithelium. In situ hybridization of adult eye sections localized transcripts only to the perivascular cells, surrounding retinal arterioles, in the ganglion cell/nerve fiber layer. Also expressed by islet cells (at protein level).

亚细胞定位

Cell membrane; Multi-pass membrane protein