跨膜糖蛋白 NMB (造血生长因子诱导性神经激肽-1型)
跨膜糖蛋白 NMB (造血生长因子诱导性神经激肽-1型)
Q14956功能描述
可能是一种黑色素生成酶。 {ECO:0000250}。
组织特异性
Widely expressed, but very low expression, if any, in the brain (PubMed:12609765, PubMed:16609006). Expressed in the epidermis with higher levels in melanocytes compared with keratinocytes and Langerhans cells (at protein level) (PubMed:29336782). Expressed in peripheral blood, but not bone marrow mononuclear cells (PubMed:12609765). Expressed in tissue macrophages, including liver Kuppfer cells and lung alveolar macrophages, in podocytes and in some cells of the ciliary body of the eye (at protein level) (PubMed:16489096). May be overexpressed in various cancers, including melanoma and glioblastoma multiforme (PubMed:16489096, PubMed:16609006, PubMed:7814155).
亚细胞定位
Cell membrane; Single-pass type I membrane protein
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