GPC6 Q9Y625

磷脂酰肌醇蛋白聚糖-6 [裂解为：分泌型磷脂酰肌醇蛋白聚糖-6]

功能描述

细胞表面蛋白聚糖，带有硫酸乙酰肝素。生长因子、细胞外基质蛋白、蛋白酶和抗蛋白酶的推定细胞表面共受体 (By similarity)。通过WNT5A信号传导增强癌细胞的迁移和侵袭。 {ECO:0000250, ECO:0000269|PubMed:21871017}。

组织特异性

Widely expressed. High expression in fetal kidney and lung and lower expressions in fetal liver and brain. In adult tissues, very abundant in ovary, high levels also observed in liver, kidney, small intestine and colon. Not detected in peripheral blood leukocytes. Detected in breast cancer cells (at protein level).

亚细胞定位

Cell membrane