磷脂酰肌醇蛋白聚糖-1 [裂解为：分泌型磷脂酰肌醇蛋白聚糖-1]
磷脂酰肌醇蛋白聚糖-1 [裂解为：分泌型磷脂酰肌醇蛋白聚糖-1]
P35052功能描述
细胞表面蛋白聚糖，带有硫酸乙酰肝素。通过硫酸乙酰肝素侧链结合alpha-4 (V)胶原蛋白，并参与施万细胞髓鞘形成（根据相似性）。可能作为催化剂，通过与两种形式的PRPN结合（通过硫酸乙酰肝素侧链），将其靶向脂筏并促进它们的相互作用，从而增加朊蛋白PRPN(C)转化为PRNP(Sc)的速率。通过将FGF2隔离在脂筏中防止其与受体(FGFRs)结合并抑制FGF介导的信号传导，从而为骨骼肌的正常分化所必需。 {ECO:0000250, ECO:0000269|PubMed:19936054, ECO:0000269|PubMed:21642435}。
亚细胞定位
Cell membrane; Lipid-anchor, GPI-anchor; Extracellular side. Endosome. Note=S-nitrosylated form recycled in endosomes. Localizes to CAV1-containing vesicles close to the cell surface. Cleavage of heparan sulfate side chains takes place mainly in late endosomes. Associates with both forms of PRNP in lipid rafts. Colocalizes with APP in perinuclear compartments and with CP in intracellular compartments. Associates with fibrillar APP amyloid-beta peptides in lipid rafts in Alzheimer disease brains.; SUBCELLULAR LOCATION: [Secreted glypican-1]: Secreted, extracellular space.
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