GMPR2 Q9P2T1

GMP还原酶2 (GMPR 2) (EC 1.7.1.7) (鸟苷5'-单磷酸氧化还原酶2) (鸟苷单磷酸还原酶2)

蛋白质信息 (UniProt)

GMP还原酶2 (GMPR 2) (EC 1.7.1.7) (鸟苷5'-单磷酸氧化还原酶2) (鸟苷单磷酸还原酶2)

Q9P2T1

功能描述

催化GMP不可逆的NADPH依赖性脱氨反应生成IMP。它参与将G的核碱基、核苷和核苷酸衍生物转化为A核苷酸，并在维持细胞内A和G核苷酸的平衡中起作用 (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469)。在调节细胞分化中发挥作用 (PubMed:12669231)。 {ECO:0000255|HAMAP-Rule:MF_03195, ECO:0000269|PubMed:12009299, ECO:0000269|PubMed:12669231, ECO:0000269|PubMed:16359702, ECO:0000269|PubMed:22037469}.

组织特异性

Highly expressed in heart, skeletal muscle, kidney, brain, liver, prostate, spleen, placenta, testis and ovary. Low expression in colon, thymus and peripheral blood leukocytes.

关键词

3D-structure Acetylation Alternative splicing Metal-binding NADP Oxidoreductase Potassium Proteomics identification Purine metabolism Reference proteome

外部链接

UniProt: Q9P2T1

NCBI Gene

GeneCards