谷氧还蛋白-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2)
谷氧还蛋白-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2)
O76003功能描述
与BOLA2协同作用，作为细胞质铁硫(Fe-S)簇组装因子，促进[2Fe-2S]簇插入到一部分细胞质蛋白中 (PubMed:26613676, PubMed:27519415)。作为心脏肥大的关键负调控因子和正性肌力调节因子 (By similarity)。血红蛋白成熟所必需 (PubMed:23615448)。不具有任何硫氧还蛋白活性，因为它缺乏催化活性所必需的保守基序。 {ECO:0000250|UniProtKB:Q9CQM9, ECO:0000269|PubMed:23615448, ECO:0000269|PubMed:26613676, ECO:0000269|PubMed:27519415}。
组织特异性
Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.
亚细胞定位
Cytoplasm, cytosol
关键词