锌指蛋白 GLI1 (胶质瘤相关癌基因) (癌基因 GLI)
锌指蛋白 GLI1 (胶质瘤相关癌基因) (癌基因 GLI)
P08151功能描述
作为转录激活因子发挥作用 (PubMed:10806483, PubMed:19706761, PubMed:19878745, PubMed:24076122, PubMed:24217340, PubMed:24311597)。结合DNA共有序列5'-GACCACCCA-3' (PubMed:2105456, PubMed:24217340, PubMed:8378770)。调节正常发育过程中特定基因的转录 (PubMed:19706761)。在颅面发育和指（趾）发育，以及中枢神经系统和胃肠道发育中起作用。介导SHH信号传导 (PubMed:19706761, PubMed:28973407)。通过其在SHH信号传导中的作用，在细胞增殖和分化中发挥作用 (PubMed:11238441, PubMed:28973407)。 {ECO:0000269|PubMed:10806483, ECO:0000269|PubMed:11238441, ECO:0000269|PubMed:19706761, ECO:0000269|PubMed:19878745, ECO:0000269|PubMed:2105456, ECO:0000269|PubMed:24076122, ECO:0000269|PubMed:24217340, ECO:0000269|PubMed:24311597, ECO:0000269|PubMed:28973407, ECO:0000269|PubMed:8378770}.; FUNCTION: [Isoform 2]: 作为转录激活因子发挥作用，但激活的基因集与isoform 1不同。与isoform 1不同，它激活CD24的表达。介导SHH信号传导。促进癌细胞迁移。 {ECO:0000269|PubMed:19706761}.
组织特异性
Detected in testis (at protein level) (PubMed:2105456). Testis, myometrium and fallopian tube. Also expressed in the brain with highest expression in the cerebellum, optic nerve and olfactory tract (PubMed:19878745). Isoform 1 is detected in brain, spleen, pancreas, liver, kidney and placenta; isoform 2 is not detectable in these tissues (PubMed:19706761).
亚细胞定位
Cytoplasm
关键词