GFRAL Q6UXV0

GDNF家族受体α样蛋白

功能描述

GDF15激素的脑干限制性受体，在应对各种压力时触发厌恶反应，特征为恶心、呕吐和/或食欲不振 (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:36630958)。这种厌恶反应既是减少暴露期间持续接触这些压力所必需的，也是促进未来回避行为所必需的 (PubMed:28846097, PubMed:28846098, PubMed:28846099, PubMed:28953886, PubMed:36630958)。GDF15-GFRAL厌恶反应由压力触发，例如抗癌药物（喜树碱或顺铂）、癌症或药物如二甲双胍 (PubMed:32661391)。与其配体GDF15相互作用后，介导GDF15诱导的RET酪氨酸激酶受体自磷酸化和激活，导致MAPK-和AKT-信号通路的激活 (PubMed:31535977, PubMed:32661391)。配体结合激活位于脑干极后区和孤束核中表达GFRAL的神经元 (By similarity)。GDF15-GFRAL信号诱导参与代谢的基因表达，例如脂肪组织中的脂质代谢 (PubMed:32661391)。 {ECO:0000250|UniProtKB:Q6SJE0, ECO:0000269|PubMed:28846097, ECO:0000269|PubMed:28846098, ECO:0000269|PubMed:28846099, ECO:0000269|PubMed:28953886, ECO:0000269|PubMed:31535977, ECO:0000269|PubMed:32661391, ECO:0000269|PubMed:36630958}。

组织特异性

Expressed in the brainstem, restricted to cells in the area postrema and the immediately adjacent region of the nucleus tractus solitarius (at protein level) (PubMed:28846097, PubMed:28846098). Detected at low levels in testis and adipose tissue (PubMed:28846097).

亚细胞定位

Cell membrane