GDNF家族受体α-3 (GDNF受体α-3) (GDNFR-α-3) (GFR-α-3)
GDNF家族受体α-3 (GDNF受体α-3) (GDNFR-α-3) (GFR-α-3)
O60609功能描述
Artemin (ARTN)的受体，ARTN是一种支持感觉和交感外周神经元存活的生长因子 (PubMed:31535977, PubMed:9883723)。ARTN结合导致RET受体的自磷酸化和激活 (PubMed:31535977, PubMed:9883723)。 {ECO:0000269|PubMed:31535977, ECO:0000269|PubMed:9883723}。
组织特异性
Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system.
亚细胞定位
Cell membrane
关键词