甘丙肽受体2型 (GAL2-R) (GALR-2)
甘丙肽受体2型 (GAL2-R) (GALR-2)
O43603功能描述
激素galanin和GALP的受体。激素spexin-1的受体 (PubMed:24517231)。该受体的活性由G蛋白介导，G蛋白激活phospholipase C/protein kinase C通路（通过G(q)）并抑制adenylyl cyclase（通过G(i)）。 {ECO:0000269|PubMed:24517231, ECO:0000269|PubMed:25691535, ECO:0000269|PubMed:9480833, ECO:0000269|PubMed:9685625, ECO:0000269|PubMed:9832121, ECO:0000269|PubMed:9880084}。
组织特异性
Expressed abundantly within the central nervous system in both hypothalamus and hippocampus. In peripheral tissues, the strongest expression was observed in heart, kidney, liver, and small intestine.
亚细胞定位
Cell membrane; Multi-pass membrane protein.
关键词