GALP Q9UBC7

甘丙肽样肽

功能描述

[Isoform 1]: 下丘脑神经肽，结合G蛋白偶联甘丙肽受体 (GALR1、GALR2和GALR3)。参与CNS稳态过程中大量推定的生理功能，包括调节促性腺激素释放激素的分泌。; FUNCTION: [Isoform 2]: 在皮肤微血管中表现出强效且剂量依赖性的血管收缩和抗水肿活性，这种生理效应似乎不是通过GALR1或GALR2介导的。表现出针对革兰氏阴性菌的抗菌活性，诱导细菌膜起泡 (PubMed:23537644)。 {ECO:0000269|PubMed:23537644}。

组织特异性

Isoform 2 is found in ganglia of ganglioneuroma and ganglioneuroblastoma, as well as in differentiated tumor cells of neuroblastoma tissues. Not found in undifferentiated neuroblasts. Isoform 2 is found in the skin, in pericytes covering microvascular arterioles and venules on their abluminal surfaces. In larger vessels, isoform 2 is expressed in layers of smooth muscle cells. Isoform 2 is not detected in endothelial cells.

亚细胞定位

Secreted.