γ-氨基丁酸受体相关蛋白样1 (早期雌激素调节蛋白) (GABA(A)受体相关蛋白样1) (腺上皮细胞蛋白1) (GEC-1)
γ-氨基丁酸受体相关蛋白样1 (早期雌激素调节蛋白) (GABA(A)受体相关蛋白样1) (腺上皮细胞蛋白1) (GEC-1)
Q9H0R8功能描述
泛素样修饰因子，通过促进受体的顺行性细胞内运输来增加kappa型阿片受体的细胞表面表达 (PubMed:16431922)。参与自噬泡的形成 (PubMed:20404487)。LC3s参与吞噬泡膜的延伸，而GABARAP/GATE-16亚家族对于自噬体成熟的后期阶段至关重要 (PubMed:20404487)。通过与网状自噬受体TEX264相互作用，参与在营养应激下将内质网亚结构域重塑为自噬体，随后与溶酶体融合以进行内质网周转 (PubMed:31006537, PubMed:31006538)。 {ECO:0000269|PubMed:16431922, ECO:0000269|PubMed:20404487, ECO:0000269|PubMed:31006537, ECO:0000269|PubMed:31006538}。
组织特异性
Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. In the brain, expression is particularly intense in motoneurons in the embryo and in neurons involved in somatomotor and neuroendocrine functions in the adult, particularly in the substantia nigra pars compacta.
亚细胞定位
Cytoplasmic vesicle, autophagosome
关键词