FTSJ1 Q9UET6

tRNA (胞苷(32)/鸟苷(34)-2'-O)-甲基转移酶 (EC 2.1.1.205) (2'-O-核糖RNA甲基转移酶TRM7同源物) (蛋白ftsJ同源物1)

功能描述

对底物tRNA反密码子环32位和34位核苷酸的2'-O-核糖进行甲基化 (PubMed:25404562, PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500)。细胞质忠实翻译所必需 (PubMed:32393790)。对底物tRNA反密码子环32位核苷酸进行甲基化需要THADA (PubMed:25404562, PubMed:26310293)。对底物tRNA反密码子环34位核苷酸进行甲基化需要WDR6 (PubMed:32558197, PubMed:33771871)。促进UUU密码子的翻译效率 (PubMed:32558197)。在神经发生中起作用 (PubMed:36720500)。参与神经发生、线粒体翻译和能量产生以及脂质生物合成的基因表达所必需 (PubMed:33771871, PubMed:36720500)。RNA介导的基因沉默所必需 (PubMed:36720500)。可能修饰tRNA(Arg(ACG))、tRNA(Arg(CCG))、tRNA(Arg(UCG))、tRNA(Cys(GCA))、tRNA(Cys(ACA))、tRNA(Gln(CUG))、tRNA(Gln(UUG))、tRNA(Gly(CCC))、tRNA(Leu(CAG))/tRNA(Leu(CAA))、tRNA(Leu(A/IAG))、tRNA(Leu(UAG))、tRNA(Phe(GAA))、tRNA(Pro(AGG))/tRNA(Pro(CGG))/tRNA(Pro(UGG))和tRNA(Trp(CCA))的32位，以及tRNA(Phe(GAA))、tRNA(Leu(CAA))、tRNA(Sec(UCA))和tRNA(Trp(CCA))的34位 (PubMed:26310293, PubMed:32198346, PubMed:32558197, PubMed:33771871, PubMed:36720500)。 {ECO:0000269|PubMed:25404562, ECO:0000269|PubMed:26310293, ECO:0000269|PubMed:32198346, ECO:0000269|PubMed:32393790, ECO:0000269|PubMed:32558197, ECO:0000269|PubMed:33771871, ECO:0000269|PubMed:36720500}。

组织特异性

Found in fetal brain, lung, liver and kidney (PubMed:15162322). Widely expressed in adult tissue; with high expression in heart and liver, lower expression in skeletal muscle, kidney, and pancreas and also lowly expressed in brain and lung (PubMed:15342698). In the adult brain, expressed in amygdala, caudate nucleus, corpus callosum, hippocampus and thalamus (PubMed:15162322).

亚细胞定位

Cytoplasm