叉头框蛋白O4 (叉头结构域转录因子AFX1)
叉头框蛋白O4 (叉头结构域转录因子AFX1)
P98177功能描述
参与胰岛素信号通路调控的转录因子。结合胰岛素应答元件(IREs)并能激活IGFBP1的转录。下调HIF1A的表达并抑制HIF1A调节基因的缺氧诱导转录激活。也参与细胞周期的负调控。参与胚胎干细胞(ESCs)中蛋白酶体活性的增加，通过激活ESCs中PSMD11的表达，促进26S蛋白酶体的组装，进而提高蛋白酶体活性。 {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}。
组织特异性
Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.
亚细胞定位
Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.
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