叉头框蛋白M1 (叉头相关蛋白FKHL16) (肝细胞核因子3叉头同源物11) (HFH-11) (HNF-3/叉头同源物11) (M期磷蛋白2) (MPM-2反应性磷蛋白2) (转录因子Trident) (来自INS-1细胞的翼状螺旋因子)
叉头框蛋白M1 (叉头相关蛋白FKHL16) (肝细胞核因子3叉头同源物11) (HFH-11) (HNF-3/叉头同源物11) (M期磷蛋白2) (MPM-2反应性磷蛋白2) (转录因子Trident) (来自INS-1细胞的翼状螺旋因子)
Q08050功能描述
调控对DNA复制和有丝分裂至关重要的细胞周期基因表达的转录因子 (PubMed:19160488, PubMed:20360045)。在细胞增殖控制中发挥作用 (PubMed:19160488)。也在DNA断裂修复中发挥作用，参与DNA损伤检查点反应 (PubMed:17101782)。促进PHB2的转录 (PubMed:33754036)。 {ECO:0000269|PubMed:17101782, ECO:0000269|PubMed:19160488, ECO:0000269|PubMed:20360045, ECO:0000269|PubMed:33754036}。
组织特异性
Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.
亚细胞定位
Nucleus.
关键词