叉头框蛋白L2
叉头框蛋白L2
P58012功能描述
转录调节因子。卵巢分化和维持以及抑制体细胞睾丸决定遗传程序的关键因子。通过转录抑制Sertoli细胞促进基因SOX9，防止卵巢向睾丸转分化 (By similarity)。在卵巢细胞中具有凋亡活性。抑制由他莫昔芬刺激的ESR1介导的PTGS2/COX2转录 (By similarity)。是CYP19表达的调节因子 (By similarity)。通过内含子SMAD结合元件参与FST的SMAD3依赖性转录 (By similarity)。是STAR的转录抑制因子。在细胞应激条件下激活SIRT1转录。激活OSR2转录。 {ECO:0000250, ECO:0000269|PubMed:16153597, ECO:0000269|PubMed:19010791, ECO:0000269|PubMed:19429596, ECO:0000269|PubMed:19744555}。
组织特异性
In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary.
亚细胞定位
Nucleus
关键词