叶酸受体α (FR-alpha) (成人叶酸结合蛋白) (FBP) (叶酸受体1) (叶酸受体, 成人) (KB细胞FBP) (卵巢肿瘤相关抗原MOv18)
叶酸受体α (FR-alpha) (成人叶酸结合蛋白) (FBP) (叶酸受体1) (叶酸受体, 成人) (KB细胞FBP) (卵巢肿瘤相关抗原MOv18)
P15328功能描述
结合叶酸和还原型叶酸衍生物，介导5-甲基四氢叶酸和叶酸类似物进入细胞内 (PubMed:19074442, PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728)。在中性pH下对叶酸和叶酸类似物具有高亲和力 (PubMed:23851396, PubMed:23934049, PubMed:2527252, PubMed:8033114, PubMed:8567728)。受体胞吞后暴露于微酸性pH环境会引发构象改变，从而显著降低其对叶酸的亲和力并介导叶酸的释放 (PubMed:8567728)。为正常的胚胎发育和正常的细胞增殖所必需 (By similarity)。 {ECO:0000250|UniProtKB:P35846, ECO:0000269|PubMed:19074442, ECO:0000269|PubMed:23851396, ECO:0000269|PubMed:23934049, ECO:0000269|PubMed:2527252, ECO:0000269|PubMed:8033114, ECO:0000269|PubMed:8567728}。
组织特异性
Primarily expressed in tissues of epithelial origin. Expression is increased in malignant tissues. Expressed in kidney, lung and cerebellum. Detected in placenta and thymus epithelium.
亚细胞定位
Cell membrane
关键词