谷氨酸羧肽酶2 (EC 3.4.17.21) (细胞生长抑制基因27蛋白) (叶酸水解酶1) (叶酰多聚-γ-谷氨酸羧肽酶) (FGCP) (谷氨酸羧肽酶II) (GCPII) (膜谷氨酸羧肽酶) (mGCP) (N-乙酰化α连接酸性二肽酶I) (NAALADase I) (前列腺特异性膜抗原) (PSM) (PSMA) (蝶酰多聚-γ-谷氨酸羧肽酶)
谷氨酸羧肽酶2 (EC 3.4.17.21) (细胞生长抑制基因27蛋白) (叶酸水解酶1) (叶酰多聚-γ-谷氨酸羧肽酶) (FGCP) (谷氨酸羧肽酶II) (GCPII) (膜谷氨酸羧肽酶) (mGCP) (N-乙酰化α连接酸性二肽酶I) (NAALADase I) (前列腺特异性膜抗原) (PSM) (PSMA) (蝶酰多聚-γ-谷氨酸羧肽酶)
Q04609功能描述
具有叶酸水解酶和N-乙酰化-α-连接-酸性二肽酶(NAALADase)活性。对三-α-谷胱甘肽肽具有偏好。在肠道中，是叶酸摄取所必需的。在脑中，通过水解神经肽N-乙酰天冬氨酰谷氨酸(NAAG)从而释放谷氨酸来调节兴奋性神经传递。参与前列腺肿瘤进展。; FUNCTION: 亦表现出二肽基肽酶IV型活性。在体外，切割Gly-Pro-AMC。
组织特异性
Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-9 is specifically expressed in prostate cancer.
亚细胞定位
Cell membrane
关键词