FLNB O75369

细丝蛋白-B (FLN-B) (ABP-278) (ABP-280同源物) (类肌动蛋白结合蛋白) (Beta-细丝蛋白) (细丝蛋白同源物1) (Fh1) (细丝蛋白-3) (甲状腺自身抗原) (截短型肌动蛋白结合蛋白) (截短型ABP)

功能描述

将细胞膜组分连接到肌动蛋白细胞骨架。可能促进肌动蛋白丝的正交分支，并将肌动蛋白丝连接到膜糖蛋白。将各种跨膜蛋白锚定到肌动蛋白细胞骨架。与FLNA的相互作用可能允许神经母细胞从脑室区迁移至皮质板。各种同工型的相互作用和定位影响肌管形态和肌发生。Isoform 6 在体外加速肌肉分化。

组织特异性

Ubiquitous. Isoform 1 and isoform 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells (HUVEC), retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord, platelet and Daudi cells. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer disease (AD). Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart.

亚细胞定位

[Isoform 1]: Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, myofibril, sarcomere, Z line. Note=In differentiating myotubes, isoform 1, isoform 2 and isoform 3 are localized diffusely throughout the cytoplasm with regions of enrichment at the longitudinal actin stress fiber. In differentiated tubes, isoform 1 is also detected within the Z-lines.; SUBCELLULAR LOCATION: [Isoform 2]: Cytoplasm, cytoskeleton, stress fiber.; SUBCELLULAR LOCATION: [Isoform 3]: Cytoplasm, cytoskeleton, stress fiber.; SUBCELLULAR LOCATION: [Isoform 6]: Cytoplasm, cytoskeleton. Note=Polarized at the periphery of myotubes.