FGFR2 P21802

成纤维细胞生长因子受体2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (角质细胞生长因子受体) (CD抗原 CD332)

功能描述

酪氨酸蛋白激酶，作为成纤维细胞生长因子的细胞表面受体，在调节细胞增殖、分化、迁移和凋亡，以及胚胎发育调节中起重要作用。为正常的胚胎模式形成、滋养层功能、肢芽发育、肺形态发生、骨发生和皮肤发育所必需。在调节成骨细胞分化、增殖和凋亡中起重要作用，并为正常骨骼发育所必需。促进角质形成细胞和未成熟成骨细胞的增殖，但促进分化成骨细胞的凋亡。磷酸化PLCG1、FRS2和PAK4。配体结合导致多种信号级联反应的激活。PLCG1的激活导致细胞信号分子二酰甘油和1,4,5-三磷酸肌醇的产生。FRS2的磷酸化触发GRB2、GAB1、PIK3R1和SOS1的募集，并介导RAS、MAPK1/ERK2、MAPK3/ERK1和MAP激酶信号通路以及AKT1信号通路的激活。FGFR2信号传导通过泛素化、内化和降解而被下调。导致激酶组成性激活或损害正常FGFR2成熟、内化和降解的突变会导致异常信号传导。过表达的FGFR2促进STAT1的激活。 {ECO:0000269|PubMed:12529371, ECO:0000269|PubMed:15190072, ECO:0000269|PubMed:15629145, ECO:0000269|PubMed:16384934, ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:17311277, ECO:0000269|PubMed:17623664, ECO:0000269|PubMed:18374639, ECO:0000269|PubMed:19103595, ECO:0000269|PubMed:19387476, ECO:0000269|PubMed:19410646, ECO:0000269|PubMed:21596750, ECO:0000269|PubMed:8663044}.

亚细胞定位

Cell membrane; Single-pass type I membrane protein. Golgi apparatus. Cytoplasmic vesicle. Note=Detected on osteoblast plasma membrane lipid rafts. After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 1]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 3]: Cell membrane; Single-pass type I membrane protein. Note=After ligand binding, the activated receptor is rapidly internalized and degraded.; SUBCELLULAR LOCATION: [Isoform 8]: Secreted.; SUBCELLULAR LOCATION: [Isoform 13]: Secreted.