成纤维细胞生长因子1 (FGF-1) (酸性成纤维细胞生长因子) (aFGF) (内皮细胞生长因子) (ECGF) (肝素结合生长因子1) (HBGF-1)
成纤维细胞生长因子1 (FGF-1) (酸性成纤维细胞生长因子) (aFGF) (内皮细胞生长因子) (ECGF) (肝素结合生长因子1) (HBGF-1)
P05230功能描述
在调节细胞存活、细胞分裂、血管生成、细胞分化和细胞迁移中发挥重要作用。在体外作为强效有丝分裂原发挥作用。作为FGFR1和整合素的配体。在肝素存在下与FGFR1结合，导致FGFR1二聚化并通过酪氨酸残基的顺序自磷酸化激活，这些残基作为相互作用蛋白的对接位点，导致多条信号级联反应的激活。与整合素ITGAV:ITGB3结合。其与整合素的结合、随后与整合素和FGFR1形成三元复合物，以及PTPN11向复合物的募集对于FGF1信号传导至关重要。诱导FGFR1、FRS2、MAPK3/ERK1、MAPK1/ERK2和AKT1的磷酸化和激活 (PubMed:18441324, PubMed:20422052)。可诱导血管生成 (PubMed:23469107)。 {ECO:0000269|PubMed:16597617, ECO:0000269|PubMed:18441324, ECO:0000269|PubMed:20145243, ECO:0000269|PubMed:20422052, ECO:0000269|PubMed:23469107, ECO:0000269|PubMed:8663044}。
组织特异性
Predominantly expressed in kidney and brain. Detected at much lower levels in heart and skeletal muscle.
亚细胞定位
Secreted. Cytoplasm. Cytoplasm, cell cortex. Cytoplasm, cytosol. Nucleus. Note=Lacks a cleavable signal sequence. Within the cytoplasm, it is transported to the cell membrane and then secreted by a non-classical pathway that requires Cu(2+) ions and S100A13. Secreted in a complex with SYT1 (By similarity). Binding of exogenous FGF1 to FGFR facilitates endocytosis followed by translocation of FGF1 across endosomal membrane into the cytosol. Nuclear import from the cytosol requires the classical nuclear import machinery, involving proteins KPNA1 and KPNB1, as well as LRRC59.
关键词