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FEZF1 A0PJY2

Fez家族锌指蛋白1 (锌指蛋白312B)

蛋白质信息 (UniProt)

Fez家族锌指蛋白1 (锌指蛋白312B)

A0PJY2

功能描述

转录阻遏蛋白。参与嗅觉感觉神经元(OSN)的轴突投射和正确终止。在前脑的嘴-尾模式化及丘脑前形成中发挥作用。OSN中的表达是细胞自主调节OSN轴突投射所必需的。非细胞自主地调节嗅球发育的层形成及中间神经元。可能为中间神经元祖细胞的正确喙侧迁移所必需(通过相似性)。{ECO:0000250}。

组织特异性

Expressed in brain. Little or no expression in other tissues. Overexpressed specifically in gastric cancers. A 2- to 20-fold increase is found in over 50% of gastric cancer tissues.

亚细胞定位

Nucleus

关键词

Alternative splicing Developmental protein Differentiation Disease variant DNA-binding Hypogonadotropic hypogonadism Kallmann syndrome Metal-binding Neurogenesis Nucleus