FERMT3 Q86UX7

Fermitin家族同源蛋白3 (Kindlin-3) (MIG2样蛋白) (Unc-112相关蛋白2)

蛋白质信息 (UniProt)

Fermitin家族同源蛋白3 (Kindlin-3) (MIG2样蛋白) (Unc-112相关蛋白2)

Q86UX7

功能描述

在造血细胞的细胞粘附中发挥核心作用 (PubMed:19234463, PubMed:26359933)。通过激活整合素 beta-1-3 (ITGB1, ITGB2 和 ITGB3) 起作用 (By similarity)。整合素介导的血小板粘附和白细胞与内皮细胞粘附所必需 (PubMed:19234460)。多形核粒细胞 (PMNs) 中整合素 beta-2 (ITGB2) 的激活所必需 (By similarity)。 {ECO:0000250|UniProtKB:Q8K1B8, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463, ECO:0000269|PubMed:26359933}.; FUNCTION: Isoform 2 可能作为 NF-kappa-B 和细胞凋亡的抑制因子。 {ECO:0000269|PubMed:19064721, ECO:0000269|PubMed:19234460, ECO:0000269|PubMed:19234463}.

组织特异性

Highly expressed in lymph node. Expressed in thymus, spleen and leukocytes. Weakly expressed in placenta, small intestine, stomach, testis and lung. Overexpressed in B-cell malignancies.

亚细胞定位

Cell projection, podosome

关键词

3D-structure Alternative splicing Cell adhesion Cell junction Cell projection Direct protein sequencing Disease variant Phosphoprotein Proteomics identification Reference proteome

外部链接

UniProt: Q86UX7

NCBI Gene

GeneCards