FER P16591

酪氨酸蛋白激酶Fer (EC 2.7.10.2) (猫脑炎病毒相关激酶FER) (藤浪禽肉瘤/猫肉瘤相关蛋白Fer) (原癌基因c-Fer) (酪氨酸激酶3) (p94-Fer)

功能描述

酪氨酸蛋白激酶，作用于生长因子细胞表面受体的下游，并在肌动蛋白细胞骨架、微管组装、片状伪足形成、细胞粘附、细胞迁移和趋化作用的调节中发挥作用。作用于EGFR、KIT、PDGFRA和PDGFRB的下游。作用于EGFR下游以促进NF-kappa-B的激活和细胞增殖。可能在有丝分裂细胞周期的调节中发挥作用。在胰岛素受体信号通路和磷脂酰肌醇3-激酶的激活中发挥作用。作用于激活的FCER1受体下游，并在肥大细胞FCER1（高亲和力免疫球蛋白epsilon受体）介导的信号传导中发挥作用。在肥大细胞脱颗粒的调节中发挥作用。在细菌脂多糖（LPS）响应的白细胞募集和渗出中发挥作用。在突触组织、突触囊泡运输、兴奋性突触后电流产生和神经元-神经元突触传递中发挥作用。在脑损伤后的神经元细胞死亡中发挥作用。磷酸化CTTN、CTNND1、PTK2/FAK1、GAB1、PECAM1和PTPN11。可能磷酸化JUP和PTPN1。能够磷酸化STAT3，但其生物学相关性取决于细胞类型和刺激。 {ECO:0000269|PubMed:12972546, ECO:0000269|PubMed:14517306, ECO:0000269|PubMed:19147545, ECO:0000269|PubMed:19339212, ECO:0000269|PubMed:19738202, ECO:0000269|PubMed:20111072, ECO:0000269|PubMed:21518868, ECO:0000269|PubMed:22223638, ECO:0000269|PubMed:7623846, ECO:0000269|PubMed:9722593}。

组织特异性

Isoform 1 is detected in normal colon and in fibroblasts (at protein level). Isoform 3 is detected in normal testis, in colon carcinoma-derived metastases in lung, liver and ovary, and in colon carcinoma and hepato carcinoma cell lines (at protein level). Isoform 3 is not detected in normal colon or in normal fibroblasts (at protein level). Widely expressed.

亚细胞定位

Cytoplasm. Cytoplasm, cytoskeleton. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection. Cell junction. Membrane; Peripheral membrane protein; Cytoplasmic side. Nucleus. Cytoplasm, cell cortex. Note=Associated with the chromatin. Detected on microtubules in polarized and motile vascular endothelial cells. Colocalizes with F-actin at the cell cortex. Colocalizes with PECAM1 and CTNND1 at nascent cell-cell contacts.